Principal Research Associate/Associate Scientist, Cell Biology About Magnet Biomedicine Magnet Biomedicine is a fast-paced, collaborative, venture-backed startup developing rational approaches to molecular glue discovery. Magnet's TrueGlueTM Discovery Platform enables the discovery and development of fit-for-purpose molecular glue strategies to target a diverse array of target classes. Our mission is to generate novel protein-protein interactions to modulate target functions, thereby revolutionizing the field of targeted therapeutics and drug discovery. We are seeking a highly motivated and experienced, full-time BS/MS level cell and molecular biologist to join our dynamic team, based out of 321 Harrison Ave, Boston, MA. We offer a competitive compensation package as well as comprehensive benefits. Job description Principal Research Associate/Associate Scientist, Cell Biology As a Principal Research Associate/Associate Scientist on the biology team at Magnet Biomedicine, you will play a pivotal role in designing, executing, and interpreting experiments to develop assays for modulating protein-protein interactions using small molecules. This position offers a unique opportunity to contribute to the development of Magnet's next-generation TrueGlue therapies. You will conduct phenotypic cell-based assays, enzymatic assays, binding experiments, in addition to biochemical and cellular screens. You will collaborate with a team of passionate scientists to discover and develop molecular glue therapeutics. Key Responsibilities Plan and execute cellular and biochemical assays (enzyme activity assays, growth and viability assays, HTRF, etc.). Perform and contribute to multi-plexed HTS screening assays. Lead CRISPR-Cas9 perturbations and downstream analysis. Evaluate protein-protein interactions through NanoBiT, IP-MS, ALPHAscreen, etc. Large scale proteomic sample preparation Perform cell line engineering and QC. Reporter and phenotypic assay development and implementation. Maintain impeccable experimental records in an ELN. Independently identify and solve technical experimental problems. Collaborate closely with all members of the Magnet team. Other duties, as assigned. Required qualifications and skills Bachelors or Masters degree in biology or related discipline and 3-5+ years experience in a biotech or pharmaceutical setting Experience in human cell culture techniques for diverse cell types, including cell line engineering and QC Expertise in cellular and molecular biology, including reporter systems and phenotypic assays Ability to perform meticulous experimental planning, execution, and analysis Strong analytical mindset and knowledge of relevant statistical methods Intellectual curiosity and a positive, collegial attitude Expertise with lentiviral packaging and transduction to generate engineered cell systems Ability to work at scale in 384-well format; handle/expand cells for HTS and follow-up experiments Experience in oncology and/or immunology, with a basic understanding of the human genetics in those areas and target dependency Hands-on experience with small-molecule binding/inhibition assays Preferred qualifications Experience with B and T cell models Experience with molecular glue therapies or bifunctional molecules Proficiency in confocal and fluorescent microscopy Working knowledge of DNA-encoded library screening Setup and execution of proteomic workflows and sample prep Experience with HTRF, AlphaLISA, and bioluminescence assays Propagation of primary cells Background in protein biochemistry Please apply at